Lung Extracellular Matrix and Fibroblast Function
نویسندگان
چکیده
منابع مشابه
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a chronic progressively fatal disease. Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is a glycosylated transmembrane protein that induces the expression of some matrix metalloproteinase (MMP) in neighboring stromal cells through direct epithelial-stromal interactions. EMMPRIN is highly expressed in type II alveolar epithelial cells at...
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The cardiac fibroblast is the most abundant cell type present in the myocardium and is mainly responsible for the deposition of extracellular matrix (ECM). Important components of cardiac ECM include structural and adhesive proteins such as collagen and fibronectin. Excess deposition of cardiac ECM (fibrosis) has been associated with the pathophysiological mechanical overload of the heart. Ther...
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Substantial evidence suggests that not only does the structure of the cardiac extracellular matrix affect the mechanical properties of myocardium, but that mechanical loading affects the synthesis of the extracellular matrix. However, loading conditions in vivo are nonhomogeneous and multiaxial. An experimental approach that combines mechanics and cell biology is used to examine the mechanisms ...
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Pulmonary fibrosis affects millions worldwide and, even though there has been a significant investment in understanding the processes involved in wound healing and maladaptive repair, a complete understanding of the mechanisms responsible for lung fibrogenesis eludes us, and interventions capable of reversing or halting disease progression are not available. Pulmonary fibrosis is characterized ...
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Exposure of the human skin to acute solar ultraviolet (UV) irradiation induces several members of the matrix metalloproteinase family (MMPs), which degrade collagen fibrils and other components of the dermal extracellular matrix (ECM) (Fisher et al., 1996; Yaar and Gilchrest, 2007). Elevation of MMPs due to chronic sun exposure can promote accumulation of dermal ECM fragmentation, which contrib...
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ژورنال
عنوان ژورنال: Annals of the American Thoracic Society
سال: 2015
ISSN: 2329-6933,2325-6621
DOI: 10.1513/annalsats.201406-240mg